Pesquisa | BVS IEC

1.

Post-gastrulation synthetic embryos generated ex utero from mouse naive ESCs.

Tarazi, Shadi; Aguilera-Castrejon, Alejandro; Joubran, Carine; Ghanem, Nadir; Ashouokhi, Shahd; Roncato, Francesco; Wildschutz, Emilie; Haddad, Montaser; Oldak, Bernardo; Gomez-Cesar, Elidet; Livnat, Nir; Viukov, Sergey; Lokshtanov, Dmitry; Naveh-Tassa, Segev; Rose, Max; Hanna, Suhair; Raanan, Calanit; Brenner, Ori; Kedmi, Merav; Keren-Shaul, Hadas; Lapidot, Tsvee; Maza, Itay; Novershtern, Noa; Hanna, Jacob H.

Cell ; 185(18): 3290-3306.e25, 2022 09 01.

Artigo em Inglês | MEDLINE | ID: mdl-35988542

2.

Deciphering the "m⁶A Code" via Antibody-Independent Quantitative Profiling.

Garcia-Campos, Miguel Angel; Edelheit, Sarit; Toth, Ursula; Safra, Modi; Shachar, Ran; Viukov, Sergey; Winkler, Roni; Nir, Ronit; Lasman, Lior; Brandis, Alexander; Hanna, Jacob H; Rossmanith, Walter; Schwartz, Schraga.

Cell ; 178(3): 731-747.e16, 2019 07 25.

Artigo em Inglês | MEDLINE | ID: mdl-31257032

3.

SOX17 is a critical specifier of human primordial germ cell fate.

Irie, Naoko; Weinberger, Leehee; Tang, Walfred W C; Kobayashi, Toshihiro; Viukov, Sergey; Manor, Yair S; Dietmann, Sabine; Hanna, Jacob H; Surani, M Azim.

Cell ; 160(1-2): 253-68, 2015 Jan 15.

Artigo em Inglês | MEDLINE | ID: mdl-25543152

4.

SUMOylation of linker histone H1 drives chromatin condensation and restriction of embryonic cell fate identity.

Sheban, Daoud; Shani, Tom; Maor, Roey; Aguilera-Castrejon, Alejandro; Mor, Nofar; Oldak, Bernardo; Shmueli, Merav D; Eisenberg-Lerner, Avital; Bayerl, Jonathan; Hebert, Jakob; Viukov, Sergey; Chen, Guoyun; Kacen, Assaf; Krupalnik, Vladislav; Chugaeva, Valeriya; Tarazi, Shadi; Rodríguez-delaRosa, Alejandra; Zerbib, Mirie; Ulman, Adi; Masarwi, Solaiman; Kupervaser, Meital; Levin, Yishai; Shema, Efrat; David, Yael; Novershtern, Noa; Hanna, Jacob H; Merbl, Yifat.

Mol Cell ; 82(1): 106-122.e9, 2022 01 06.

Artigo em Inglês | MEDLINE | ID: mdl-34875212

5.

Transcriptional programs that control expression of the autoimmune regulator gene Aire.

Herzig, Yonatan; Nevo, Shir; Bornstein, Chamutal; Brezis, Miriam R; Ben-Hur, Sharon; Shkedy, Aya; Eisenberg-Bord, Michal; Levi, Ben; Delacher, Michael; Goldfarb, Yael; David, Eyal; Weinberger, Leehee; Viukov, Sergey; Ben-Dor, Shifra; Giraud, Matthieu; Hanna, Jacob H; Breiling, Achim; Lyko, Frank; Amit, Ido; Feuerer, Markus; Abramson, Jakub.

Nat Immunol ; 18(2): 161-172, 2017 02.

Artigo em Inglês | MEDLINE | ID: mdl-27941786

6.

Complete human day 14 post-implantation embryo models from naive ES cells.

Oldak, Bernardo; Wildschutz, Emilie; Bondarenko, Vladyslav; Comar, Mehmet-Yunus; Zhao, Cheng; Aguilera-Castrejon, Alejandro; Tarazi, Shadi; Viukov, Sergey; Pham, Thi Xuan Ai; Ashouokhi, Shahd; Lokshtanov, Dmitry; Roncato, Francesco; Ariel, Eitan; Rose, Max; Livnat, Nir; Shani, Tom; Joubran, Carine; Cohen, Roni; Addadi, Yoseph; Chemla, Muriel; Kedmi, Merav; Keren-Shaul, Hadas; Pasque, Vincent; Petropoulos, Sophie; Lanner, Fredrik; Novershtern, Noa; Hanna, Jacob H.

Nature ; 622(7983): 562-573, 2023 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-37673118

7.

Context-dependent functional compensation between Ythdf m⁶A reader proteins.

Lasman, Lior; Krupalnik, Vladislav; Viukov, Sergey; Mor, Nofar; Aguilera-Castrejon, Alejandro; Schneir, Dan; Bayerl, Jonathan; Mizrahi, Orel; Peles, Shani; Tawil, Shadi; Sathe, Shashank; Nachshon, Aharon; Shani, Tom; Zerbib, Mirie; Kilimnik, Itay; Aigner, Stefan; Shankar, Archana; Mueller, Jasmine R; Schwartz, Schraga; Stern-Ginossar, Noam; Yeo, Gene W; Geula, Shay; Novershtern, Noa; Hanna, Jacob H.

Genes Dev ; 34(19-20): 1373-1391, 2020 10 01.

Artigo em Inglês | MEDLINE | ID: mdl-32943573

8.

NKp46 Receptor-Mediated Interferon-Î³ Production by Natural Killer Cells Increases Fibronectin 1 to Alter Tumor Architecture and Control Metastasis.

Glasner, Ariella; Levi, Assi; Enk, Jonatan; Isaacson, Batya; Viukov, Sergey; Orlanski, Shari; Scope, Alon; Neuman, Tzahi; Enk, Claes D; Hanna, Jacob H; Sexl, Veronika; Jonjic, Stipan; Seliger, Barbara; Zitvogel, Laurence; Mandelboim, Ofer.

Immunity ; 48(1): 107-119.e4, 2018 01 16.

Artigo em Inglês | MEDLINE | ID: mdl-29329948

9.

Ex utero mouse embryogenesis from pre-gastrulation to late organogenesis.

Aguilera-Castrejon, Alejandro; Oldak, Bernardo; Shani, Tom; Ghanem, Nadir; Itzkovich, Chen; Slomovich, Sharon; Tarazi, Shadi; Bayerl, Jonathan; Chugaeva, Valeriya; Ayyash, Muneef; Ashouokhi, Shahd; Sheban, Daoud; Livnat, Nir; Lasman, Lior; Viukov, Sergey; Zerbib, Mirie; Addadi, Yoseph; Rais, Yoach; Cheng, Saifeng; Stelzer, Yonatan; Keren-Shaul, Hadas; Shlomo, Raanan; Massarwa, Rada; Novershtern, Noa; Maza, Itay; Hanna, Jacob H.

Nature ; 593(7857): 119-124, 2021 05.

Artigo em Inglês | MEDLINE | ID: mdl-33731940

10.

NKp46 Receptor-Mediated Interferon-Î³ Production by Natural Killer Cells Increases Fibronectin 1 to Alter Tumor Architecture and Control Metastasis.

Glasner, Ariella; Levi, Assi; Enk, Jonatan; Isaacson, Batya; Viukov, Sergey; Orlanski, Shari; Scope, Alon; Neuman, Tzahi; Enk, Claes D; Hanna, Jacob H; Sexl, Veronika; Jonjic, Stipan; Seliger, Barbara; Zitvogel, Laurence; Mandelboim, Ofer.

Immunity ; 48(2): 396-398, 2018 02 20.

Artigo em Inglês | MEDLINE | ID: mdl-29466761

11.

Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis.

Yona, Simon; Kim, Ki-Wook; Wolf, Yochai; Mildner, Alexander; Varol, Diana; Breker, Michal; Strauss-Ayali, Dalit; Viukov, Sergey; Guilliams, Martin; Misharin, Alexander; Hume, David A; Perlman, Harris; Malissen, Bernard; Zelzer, Elazar; Jung, Steffen.

Immunity ; 38(1): 79-91, 2013 Jan 24.

Artigo em Inglês | MEDLINE | ID: mdl-23273845

12.

Derivation of novel human ground state naive pluripotent stem cells.

Gafni, Ohad; Weinberger, Leehee; Mansour, Abed AlFatah; Manor, Yair S; Chomsky, Elad; Ben-Yosef, Dalit; Kalma, Yael; Viukov, Sergey; Maza, Itay; Zviran, Asaf; Rais, Yoach; Shipony, Zohar; Mukamel, Zohar; Krupalnik, Vladislav; Zerbib, Mirie; Geula, Shay; Caspi, Inbal; Schneir, Dan; Shwartz, Tamar; Gilad, Shlomit; Amann-Zalcenstein, Daniela; Benjamin, Sima; Amit, Ido; Tanay, Amos; Massarwa, Rada; Novershtern, Noa; Hanna, Jacob H.

Nature ; 504(7479): 282-6, 2013 Dec 12.

Artigo em Inglês | MEDLINE | ID: mdl-24172903

13.

Deterministic direct reprogramming of somatic cells to pluripotency.

Rais, Yoach; Zviran, Asaf; Geula, Shay; Gafni, Ohad; Chomsky, Elad; Viukov, Sergey; Mansour, Abed AlFatah; Caspi, Inbal; Krupalnik, Vladislav; Zerbib, Mirie; Maza, Itay; Mor, Nofar; Baran, Dror; Weinberger, Leehee; Jaitin, Diego A; Lara-Astiaso, David; Blecher-Gonen, Ronnie; Shipony, Zohar; Mukamel, Zohar; Hagai, Tzachi; Gilad, Shlomit; Amann-Zalcenstein, Daniela; Tanay, Amos; Amit, Ido; Novershtern, Noa; Hanna, Jacob H.

Nature ; 502(7469): 65-70, 2013 Oct 03.

Artigo em Inglês | MEDLINE | ID: mdl-24048479

14.

The H3K27 demethylase Utx regulates somatic and germ cell epigenetic reprogramming.

Mansour, Abed AlFatah; Gafni, Ohad; Weinberger, Leehee; Zviran, Asaf; Ayyash, Muneef; Rais, Yoach; Krupalnik, Vladislav; Zerbib, Mirie; Amann-Zalcenstein, Daniela; Maza, Itay; Geula, Shay; Viukov, Sergey; Holtzman, Liad; Pribluda, Ariel; Canaani, Eli; Horn-Saban, Shirley; Amit, Ido; Novershtern, Noa; Hanna, Jacob H.

Nature ; 488(7411): 409-13, 2012 Aug 16.

Artigo em Inglês | MEDLINE | ID: mdl-22801502

15.

Corrigendum: Deterministic direct reprogramming of somatic cells to pluripotency.

Rais, Yoach; Zviran, Asaf; Geula, Shay; Gafni, Ohad; Chomsky, Elad; Viukov, Sergey; Mansour, Abed AlFatah; Caspi, Inbal; Krupalnik, Vladislav; Zerbib, Mirie; Maza, Itay; Mor, Nofar; Baran, Dror; Weinberger, Leehee; Jaitin, Diego A; Lara-Astiaso, David; Blecher-Gonen, Ronnie; Shipony, Zohar; Mukamel, Zohar; Hagai, Tzachi; Gilad, Shlomit; Amann-Zalcenstein, Daniela; Tanay, Amos; Amit, Ido; Novershtern, Noa; Hanna, Jacob H.

Nature ; 520(7549): 710, 2015 Apr 30.

Artigo em Inglês | MEDLINE | ID: mdl-25830885

16.

Corrigendum: Derivation of novel human ground state naive pluripotent stem cells.

Gafni, Ohad; Weinberger, Leehee; Mansour, Abed AlFatah; Manor, Yair S; Chomsky, Elad; Ben-Yosef, Dalit; Kalma, Yael; Viukov, Sergey; Maza, Itay; Zviran, Asaf; Rais, Yoach; Shipony, Zohar; Mukamel, Zohar; Krupalnik, Vladislav; Zerbib, Mirie; Geula, Shay; Caspi, Inbal; Schneir, Dan; Shwartz, Tamar; Gilad, Shlomit; Amann-Zalcenstein, Daniela; Benjamin, Sima; Amit, Ido; Tanay, Amos; Massarwa, Rada; Novershtern, Noa; Hanna, Jacob H.

Nature ; 520(7549): 710, 2015 Apr 30.

Artigo em Inglês | MEDLINE | ID: mdl-25830888

17.

Human primed and naïve PSCs are both able to differentiate into trophoblast stem cells.

Viukov, Sergey; Shani, Tom; Bayerl, Jonathan; Aguilera-Castrejon, Alejandro; Oldak, Bernardo; Sheban, Daoud; Tarazi, Shadi; Stelzer, Yonatan; Hanna, Jacob H; Novershtern, Noa.

Stem Cell Reports ; 17(11): 2484-2500, 2022 11 08.

Artigo em Inglês | MEDLINE | ID: mdl-36270280

18.

Modeling genetic epileptic encephalopathies using brain organoids.

Steinberg, Daniel J; Repudi, Srinivasarao; Saleem, Afifa; Kustanovich, Irina; Viukov, Sergey; Abudiab, Baraa; Banne, Ehud; Mahajnah, Muhammad; Hanna, Jacob H; Stern, Shani; Carlen, Peter L; Aqeilan, Rami I.

EMBO Mol Med ; 13(8): e13610, 2021 08 09.

Artigo em Inglês | MEDLINE | ID: mdl-34268881

19.

Principles of signaling pathway modulation for enhancing human naive pluripotency induction.

Bayerl, Jonathan; Ayyash, Muneef; Shani, Tom; Manor, Yair Shlomo; Gafni, Ohad; Massarwa, Rada; Kalma, Yael; Aguilera-Castrejon, Alejandro; Zerbib, Mirie; Amir, Hadar; Sheban, Daoud; Geula, Shay; Mor, Nofar; Weinberger, Leehee; Naveh Tassa, Segev; Krupalnik, Vladislav; Oldak, Bernardo; Livnat, Nir; Tarazi, Shadi; Tawil, Shadi; Wildschutz, Emilie; Ashouokhi, Shahd; Lasman, Lior; Rotter, Varda; Hanna, Suhair; Ben-Yosef, Dalit; Novershtern, Noa; Viukov, Sergey; Hanna, Jacob H.

Cell Stem Cell ; 28(9): 1549-1565.e12, 2021 09 02.

Artigo em Inglês | MEDLINE | ID: mdl-33915080

20.

Deterministic Somatic Cell Reprogramming Involves Continuous Transcriptional Changes Governed by Myc and Epigenetic-Driven Modules.

Zviran, Asaf; Mor, Nofar; Rais, Yoach; Gingold, Hila; Peles, Shani; Chomsky, Elad; Viukov, Sergey; Buenrostro, Jason D; Scognamiglio, Roberta; Weinberger, Leehee; Manor, Yair S; Krupalnik, Vladislav; Zerbib, Mirie; Hezroni, Hadas; Jaitin, Diego Adhemar; Larastiaso, David; Gilad, Shlomit; Benjamin, Sima; Gafni, Ohad; Mousa, Awni; Ayyash, Muneef; Sheban, Daoud; Bayerl, Jonathan; Aguilera-Castrejon, Alejandro; Massarwa, Rada; Maza, Itay; Hanna, Suhair; Stelzer, Yonatan; Ulitsky, Igor; Greenleaf, William J; Tanay, Amos; Trumpp, Andreas; Amit, Ido; Pilpel, Yitzhak; Novershtern, Noa; Hanna, Jacob H.

Cell Stem Cell ; 24(2): 328-341.e9, 2019 02 07.

Artigo em Inglês | MEDLINE | ID: mdl-30554962

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Post-gastrulation synthetic embryos generated ex utero from mouse naive ESCs.

Deciphering the "m⁶A Code" via Antibody-Independent Quantitative Profiling.

SOX17 is a critical specifier of human primordial germ cell fate.

SUMOylation of linker histone H1 drives chromatin condensation and restriction of embryonic cell fate identity.

Transcriptional programs that control expression of the autoimmune regulator gene Aire.

Complete human day 14 post-implantation embryo models from naive ES cells.

Context-dependent functional compensation between Ythdf m⁶A reader proteins.

NKp46 Receptor-Mediated Interferon-Î³ Production by Natural Killer Cells Increases Fibronectin 1 to Alter Tumor Architecture and Control Metastasis.

Ex utero mouse embryogenesis from pre-gastrulation to late organogenesis.

NKp46 Receptor-Mediated Interferon-Î³ Production by Natural Killer Cells Increases Fibronectin 1 to Alter Tumor Architecture and Control Metastasis.

Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis.

Derivation of novel human ground state naive pluripotent stem cells.

Deterministic direct reprogramming of somatic cells to pluripotency.

The H3K27 demethylase Utx regulates somatic and germ cell epigenetic reprogramming.

Corrigendum: Deterministic direct reprogramming of somatic cells to pluripotency.

Corrigendum: Derivation of novel human ground state naive pluripotent stem cells.

Human primed and naïve PSCs are both able to differentiate into trophoblast stem cells.

Modeling genetic epileptic encephalopathies using brain organoids.

Principles of signaling pathway modulation for enhancing human naive pluripotency induction.

Deterministic Somatic Cell Reprogramming Involves Continuous Transcriptional Changes Governed by Myc and Epigenetic-Driven Modules.